KMID : 0880220070450030234
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Journal of Microbiology 2007 Volume.45 No. 3 p.234 ~ p.240
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Expression of Escherichia coli DcuS-R Two-Component Regulatory System is Regulated by the Secondary Internal Promoter Which is Activated by CRP-cAMP
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Oyamada Tomoya
Yokoyama Katsushi Morinaga Michiko Suzuki Masashi Makino Kozo
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Abstract
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The DcuS-R two-component system of Escherichia coli senses C4-dicarboxylates of the medium and regulates expression of the genes related to utilization of them. It is known that phospho-DcuR induces expression of genes such as the dcuB-fumB operon, the frdABCD operon, and the dctA gene. We analyzed promoters of the dcuS-R operon to elucidate the transcriptional regulation system. We found a novel internal promoter within the dcuS gene that is regulated by the transcriptional regulator, CRP-cAMP, in both aerobic and anaerobic conditions.
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KEYWORD
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CRP, cAMP, two-component regulatory system
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